Homo sapiens Protein: SNX18
Summary
InnateDB Protein IDBP-20658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX18
Protein Name sorting nexin 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000317332
InnateDB Gene IDBG-20654 (SNX18)
Protein Structure
UniProt Annotation
Function Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane. {ECO:0000269PubMed:18411244, ECO:0000269PubMed:20427313, ECO:0000269PubMed:21048941, ECO:0000269PubMed:22718350}.
Subcellular Localization Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007067 mitotic nuclear division
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0036089 cleavage furrow formation
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030136 clathrin-coated vesicle
GO:0030426 growth cone
GO:0030659 cytoplasmic vesicle membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
IPR014536 Sorting nexin 9 subfamily
IPR019497 Sorting nexin protein, WASP-binding domain
PFAM PF00018
PF14604
PF00787
PF07653
PF10456
PRINTS PR00452
PIRSF PIRSF027744
SMART SM00326
SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RF0
PhosphoSite PhosphoSite-Q96RF0
TrEMBL
UniProt Splice Variant
Entrez Gene 112574
UniGene Hs.606166
RefSeq NP_443102
HUGO HGNC:19245
OMIM
CCDS CCDS3962
HPRD 15407
IMGT
EMBL AC091888 AF395536 AK304195 BC060791 BC067860 BC117218 BC117220 CH471123
GenPept AAH60791 AAH67860 AAI17219 AAI17221 AAK82415 BAG65075 EAW54894