InnateDB Protein
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IDBP-206686.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Uncx
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Protein Name
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UNC homeobox
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Synonyms
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Chx4; Uncx4.1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000031523
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InnateDB Gene
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IDBG-206684 (Uncx)
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Protein Structure
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Function |
Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions. {ECO:0000269PubMed:10804168, ECO:0000269PubMed:10804169, ECO:0000269PubMed:16461927}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
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Disease Associations |
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Tissue Specificity |
Expressed in the paraxial mesoderm, in the developing kidney and central nervous system. In the somite, it is restricted to the caudal half of the newly formed somite and sclerotome. In the central nervous system, it is detected in the developing spinal cord, hindbrain, mesencephalon and telencephalon. Expressed in adult and embryonic magnocellular neurons of the hypothalamo-neurohypophysial system. {ECO:0000269PubMed:10330372, ECO:0000269PubMed:10545229, ECO:0000269PubMed:11747084, ECO:0000269PubMed:11973278, ECO:0000269PubMed:16461927, ECO:0000269PubMed:16728472, ECO:0000269PubMed:17477400, ECO:0000269PubMed:17531978, ECO:0000269PubMed:9286595}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:108013
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
O08934
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22255
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UniGene |
Mm.42190
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RefSeq |
NP_038730
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MGI ID |
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MGI Symbol |
Uncx
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OMIM |
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CCDS |
CCDS19813
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HPRD |
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IMGT |
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EMBL |
AF247550
AH006754
AJ001116
BC051973
Z96107
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GenPept |
AAC52830
AAF71322
AAH51973
CAA04542
CAB09537
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