InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chd5

Summary

InnateDB Protein

IDBP-206691.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Chd5

Protein Name

chromodomain helicase DNA binding protein 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005175

InnateDB Gene

IDBG-206687 (Chd5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0035064	methylated histone binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0021895	cerebral cortex neuron differentiation
GO:0035093	spermatogenesis, exchange of chromosomal proteins
GO:0043967	histone H4 acetylation
GO:0045595	regulation of cell differentiation
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0098532	histone H3-K27 trimethylation
GO:1901798	positive regulation of signal transduction by p53 class mediator

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0016581	NuRD complex

Protein Structure and Domains

PDB ID

MGI:3036258

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR001965 Zinc finger, PHD-type
IPR006935 Helicase/UvrB domain
IPR009071 High mobility group box domain
IPR009462 Domain of unknown function DUF1086
IPR009463 Domain of unknown function DUF1087
IPR011011 Zinc finger, FYVE/PHD-type
IPR012957 CHD, C-terminal 2
IPR012958 CHD, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR019787 Zinc finger, PHD-finger
IPR021006 Histone deacetylase complex, subunit 2/3
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM