InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lyve1

Summary

InnateDB Protein

IDBP-206694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lyve1

Protein Name

lymphatic vessel endothelial hyaluronan receptor 1

Synonyms

1200012G08Rik; Crsbp-1; Lyve-1; Xlkd1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033050

InnateDB Gene

IDBG-206692 (Lyve1)

Protein Structure

UniProt Annotation

Function

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269PubMed:10187853}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10187853}; Single-pass type I membrane protein {ECO:0000269PubMed:10187853}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005540	hyaluronic acid binding

Biological Process

GO:0006027	glycosaminoglycan catabolic process
GO:0006810	transport
GO:0007155	cell adhesion
GO:0007165	signal transduction

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:2136348

InterPro

IPR000538 Link
IPR016187 C-type lectin fold

PFAM

PF00193

PRINTS

PR01265

PIRSF

SMART

SM00445

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BHC0

PhosphoSite

PhosphoSite-Q8BHC0

TrEMBL

UniProt Splice Variant

Entrez Gene

114332

UniGene

Mm.470516

RefSeq

NP_444477

MGI ID

MGI Symbol

Lyve1

OMIM

CCDS

CCDS21748

HPRD

IMGT

EMBL

AJ311501 AK004726 AK160857 BC038653 BC038892

GenPept

AAH38653 AAH38892 BAC25094 BAE36050 CAC33082