InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DSG3

Summary

InnateDB Protein

IDBP-2067.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DSG3

Protein Name

desmoglein 3

Synonyms

CDHF6; PVA;

Species

Homo sapiens

Ensembl Protein

ENSP00000257189

InnateDB Gene

IDBG-2065 (DSG3)

Protein Structure

UniProt Annotation

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Epidermis, tongue, tonsil, esophagus and carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007156	homophilic cell adhesion

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030057	desmosome
GO:0070062	extracellular vesicular exosome