Version 5.4
Mus musculus Protein: Mrvi1
Summary
InnateDB Protein IDBP-206715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mrvi1
Protein Name MRV integration site 1
Synonyms BB115629; Irag; Ris1;
Species Mus musculus
Ensembl Protein ENSMUSP00000005751
InnateDB Gene IDBG-206713 (Mrvi1)
Protein Structure
UniProt Annotation
Function Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. {ECO:0000269PubMed:10321731, ECO:0000269PubMed:15388327, ECO:0000269PubMed:15483626, ECO:0000269PubMed:16990611}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269PubMed:15388327}. Sarcoplasmic reticulum {ECO:0000269PubMed:15388327}.
Disease Associations
Tissue Specificity Highly expressed in smooth muscle such as aorta, colon and uterus. Detected in the brain, in the thalamus, in the hippocampus and myenteric plexus. Highly expressed in megakaryocytes. Down-regulated during macrophage differentiation. {ECO:0000269PubMed:10321731, ECO:0000269PubMed:15388327, ECO:0000269PubMed:16141072}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0019934 cGMP-mediated signaling
GO:0045986 negative regulation of smooth muscle contraction
GO:0060087 relaxation of vascular smooth muscle
Cellular Component
GO:0016021 integral component of membrane
GO:0016529 sarcoplasmic reticulum
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1338023
InterPro IPR008677 MRVI1
PFAM PF05781
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUX5
PhosphoSite PhosphoSite-Q9WUX5
TrEMBL D3YUG8
UniProt Splice Variant
Entrez Gene 17540
UniGene Mm.490772
RefSeq NP_919446
MGI ID
MGI Symbol Mrvi1
OMIM
CCDS CCDS21749
HPRD
IMGT
EMBL AC159206 AC184052 AK157169 U63407 U63408
GenPept AAD22568 AAD22569 BAE33986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca