InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctr9

Summary

InnateDB Protein

IDBP-206755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctr9

Protein Name

Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Synonyms

AA409336; mKIAA0155; Sh2bp1; Tsbp; Tsp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005749

InnateDB Gene

IDBG-206751 (Ctr9)

Protein Structure

UniProt Annotation

Function

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys- 4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Required for mono- and trimethylation on histone H3 'Lys- 4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (By similarity). Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3. {ECO:0000250, ECO:0000269PubMed:17911113, ECO:0000269PubMed:19345177}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:8636124}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:12465718}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	16 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042169	SH2 domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001711	endodermal cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0007259	JAK-STAT cascade
GO:0010390	histone monoubiquitination
GO:0016055	Wnt signaling pathway
GO:0019827	stem cell maintenance
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523	histone H2B ubiquitination
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0070102	interleukin-6-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0080182	histone H3-K4 trimethylation
GO:2001162	positive regulation of histone H3-K79 methylation