Version 5.4
Mus musculus Protein: Dffb
Summary
InnateDB Protein IDBP-206809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dffb
Protein Name DNA fragmentation factor, beta subunit
Synonyms 40kDa; 5730477D02Rik; CAD; CPAN; DFF40; Didff;
Species Mus musculus
Ensembl Protein ENSMUSP00000030893
InnateDB Gene IDBG-206807 (Dffb)
Protein Structure
UniProt Annotation
Function Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004536 deoxyribonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
Biological Process
GO:0006309 apoptotic DNA fragmentation
GO:0006915 apoptotic process
GO:0007420 brain development
GO:0030263 apoptotic chromosome condensation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1196287
InterPro IPR003508 CIDE-N domain
IPR015311 Apoptosis, DNA fragmentation factor 40kDa
PFAM PF02017
PF09230
PRINTS
PIRSF
SMART SM00266
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54788
PhosphoSite PhosphoSite-
TrEMBL Q7TS81
UniProt Splice Variant
Entrez Gene 13368
UniGene Mm.404047
RefSeq NP_031885
MGI ID 1V0D
MGI Symbol Dffb
OMIM
CCDS CCDS19004
HPRD
IMGT
EMBL AB009377 BC053052
GenPept AAH53052 BAA24977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca