InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif3b

Summary

InnateDB Protein

IDBP-206892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif3b

Protein Name

eukaryotic translation initiation factor 3, subunit B

Synonyms

AL033316; AL033334; AL033369; AW208965; D5Wsu45e; EIF3-ETA; EIF3-P110; EIF3-P116; Eif3s9; PRT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098076

InnateDB Gene

IDBG-206890 (Eif3b)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000269PubMed:12038979}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03001}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12038979}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0031369	translation initiation factor binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation

Cellular Component

GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex
GO:0070062	extracellular vesicular exosome
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m

Protein Structure and Domains

PDB ID

MGI:106478

InterPro

IPR000504 RNA recognition motif domain
IPR011400 Eukaryotic translation initiation factor 3 subunit B
IPR013979 Translation initiation factor, beta propellor-like domain

PFAM

PF00076
PF08662

PRINTS

PIRSF

PIRSF036424

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt