Version 5.4
Mus musculus Protein: Tfb2m
Summary
InnateDB Protein IDBP-206912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfb2m
Protein Name transcription factor B2, mitochondrial
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000027769
InnateDB Gene IDBG-206910 (Tfb2m)
Protein Structure
UniProt Annotation
Function S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. {ECO:0000269PubMed:15526033}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12532263}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003712 transcription cofactor activity
GO:0003723 RNA binding
GO:0008649 rRNA methyltransferase activity
Biological Process
GO:0000154 rRNA modification
GO:0006355 regulation of transcription, DNA-templated
GO:0006391 transcription initiation from mitochondrial promoter
GO:0031167 rRNA methylation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:107937
InterPro IPR001737 Ribosomal RNA adenine methylase transferase
IPR016861 Mitochondrial dimethyladenosine transferase 2, mitochondrial precursor
IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF00398
PRINTS
PIRSF PIRSF027833
SMART SM00650
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TL26
PhosphoSite PhosphoSite-Q3TL26
TrEMBL B2RSE6
UniProt Splice Variant
Entrez Gene 15278
UniGene Mm.482746
RefSeq NP_032275
MGI ID
MGI Symbol Tfb2m
OMIM
CCDS CCDS15561
HPRD
IMGT
EMBL AK090106 AK146563 AK166717 AK167930 AK168970 AK169138 BC138836 BC138837 CH466555 M74555
GenPept AAA37817 AAI38837 AAI38838 BAC41095 BAE27262 BAE38967 BAE39934 BAE40774 BAE40917 EDL13168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca