InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lfng

Summary

InnateDB Protein

IDBP-206953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lfng

Protein Name

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Synonyms

AW061165;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031555

InnateDB Gene

IDBG-206951 (Lfng)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules inhibiting Jagged mediated Notch signaling. Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-formig territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity. Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B- cell development in lymphoid progenitors. May play a role in boundary formation of the enamel knot.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected at 12.5 dpc in all tissues examined with the highest level observed in adult brain and spleen. Detected in the dental epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016757	transferase activity, transferring glycosyl groups
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001756	somitogenesis
GO:0007143	female meiotic division
GO:0007386	compartment pattern specification
GO:0007389	pattern specification process
GO:0008152	metabolic process
GO:0008593	regulation of Notch signaling pathway
GO:0014807	regulation of somitogenesis
GO:0032092	positive regulation of protein binding
GO:0045747	positive regulation of Notch signaling pathway