InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Far1

Summary

InnateDB Protein

IDBP-207100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Far1

Protein Name

fatty acyl CoA reductase 1

Synonyms

2600011M19Rik; 2900034E22Rik; 3732409C05Rik; AI850429; Mlstd2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033018

InnateDB Gene

IDBG-207098 (Far1)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. {ECO:0000269PubMed:15220348, ECO:0000269PubMed:15220349}.

Subcellular Localization

Peroxisome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in all tissues examined. Highest expression seen in preputial gland. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269PubMed:15220348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0050062	long-chain-fatty-acyl-CoA reductase activity
GO:0050662	coenzyme binding
GO:0080019	fatty-acyl-CoA reductase (alcohol-forming) activity

Biological Process

GO:0008611	ether lipid biosynthetic process
GO:0010025	wax biosynthetic process
GO:0035336	long-chain fatty-acyl-CoA metabolic process
GO:0044237	cellular metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0055114	oxidation-reduction process