Version 5.4
Mus musculus Protein: Smg8
Summary
InnateDB Protein IDBP-207202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smg8
Protein Name RIKEN cDNA 1200011M11 gene
Synonyms 1200011M11Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000020801
InnateDB Gene IDBG-207200 (Smg8)
Protein Structure
UniProt Annotation
Function Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1921383
InterPro IPR019354 Smg8/Smg9
PFAM PF10220
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VE18
PhosphoSite PhosphoSite-Q8VE18
TrEMBL
UniProt Splice Variant
Entrez Gene 74133
UniGene Mm.23257
RefSeq NP_077224
MGI ID
MGI Symbol Smg8
OMIM
CCDS CCDS25207
HPRD
IMGT
EMBL AK004714 AK031106 AK035089 AL713917 BC020005 CU407131
GenPept AAH20005 BAB23498 BAC27255 BAC28941 CAI25313 CAQ51995

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca