InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rassf2

Summary

InnateDB Protein

IDBP-207212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rassf2

Protein Name

Ras association (RalGDS/AF-6) domain family member 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099471

InnateDB Gene

IDBG-207206 (Rassf2)

Protein Structure

UniProt Annotation

Function

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0038168	epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade
GO:0045667	regulation of osteoblast differentiation
GO:0045670	regulation of osteoclast differentiation
GO:0046849	bone remodeling
GO:0048872	homeostasis of number of cells
GO:1901222	regulation of NIK/NF-kappaB signaling
GO:1901223	negative regulation of NIK/NF-kappaB signaling