InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: 2810405K02Rik

Summary

InnateDB Protein

IDBP-207218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

2810405K02Rik

Protein Name

RIKEN cDNA 2810405K02 gene

Synonyms

2810405K02Rik; AI836168; PM/PGFS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030935

InnateDB Gene

IDBG-207216 (2810405K02Rik)

Protein Structure

UniProt Annotation

Function

Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha). {ECO:0000269PubMed:18006499}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:18006499}.

Disease Associations

Tissue Specificity

Mainly present in brain and spinal cord. In spinal cord, present in the superficial layer of the dorsal horn, in motor neurons of the ventral horn and in glia of the white matter of the spinal cord. In brain, expressed preferentially in the white matter bundles of the entire CNS of adult with less marked expression in neuronal cell bodies. Colocalizes with MBP in myelin sheaths but not in axons. Localizes to myelin sheaths (at protein level). {ECO:0000269PubMed:18006499, ECO:0000269PubMed:20950588}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047017	prostaglandin-F synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0043209	myelin sheath
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1913719

InterPro

IPR012336 Thioredoxin-like fold

PFAM

PF13098
PF13192
PF13462
PF13905

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9DB60

PhosphoSite

PhosphoSite-Q9DB60

TrEMBL

UniProt Splice Variant

Entrez Gene

66469

UniGene

RefSeq

NP_079858

MGI ID

MGI Symbol

Fam213b

OMIM

CCDS

CCDS19016

HPRD

IMGT

EMBL

AK005188 AL607032 BC030453

GenPept

AAH30453 BAB23870 CAM15790