Version 5.4
Mus musculus Protein: Ska2
Summary
InnateDB Protein IDBP-207221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ska2
Protein Name family with sequence similarity 33, member A
Synonyms 1110001A07Rik; C78640; Fam33a;
Species Mus musculus
Ensembl Protein ENSMUSP00000020794
InnateDB Gene IDBG-207219 (Ska2)
Protein Structure
UniProt Annotation
Function Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0051301 cell division
Cellular Component
GO:0000940 condensed chromosome outer kinetochore
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
Protein Structure and Domains
PDB ID MGI:1913390
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CR46
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66140
UniGene Mm.45008
RefSeq NP_079653
MGI ID
MGI Symbol Ska2
OMIM
CCDS CCDS25209
HPRD
IMGT
EMBL AK003196 AK013317 AK013370 AK017811 AK162628 AL713917 BC117001 BC119167 CH466556 CU468043
GenPept AAI17002 AAI19168 BAB22634 BAB28787 BAB28814 BAB30948 BAE36998 CAI25315 CAQ51630 EDL15809

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca