InnateDB Protein
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IDBP-207280.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppm1e
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Protein Name
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protein phosphatase 1E (PP2C domain containing)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000061278
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InnateDB Gene
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IDBG-207278 (Ppm1e)
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Protein Structure
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Function |
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2. {ECO:0000250, ECO:0000269PubMed:23088624}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form, is found in the nucleus (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2444096
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InterPro |
IPR001932
Protein phosphatase 2C (PP2C)-like domain
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PFAM |
PF00481
PF07228
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PRINTS |
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PIRSF |
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SMART |
SM00331
SM00332
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TIGRFAMs |
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Modification |
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SwissProt |
Q80TL0
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PhosphoSite |
PhosphoSite-Q80TL0
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TrEMBL |
B2KGP3
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UniProt Splice Variant |
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Entrez Gene |
320472
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UniGene |
Mm.449048
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RefSeq |
NP_796141
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MGI ID |
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MGI Symbol |
Ppm1e
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OMIM |
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CCDS |
CCDS25211
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HPRD |
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IMGT |
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EMBL |
AK036583
AK046962
AK053696
AK122434
AL596130
BC138900
BC138903
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GenPept |
AAI38901
AAI38904
BAC29490
BAC32927
BAC35479
BAC65716
CAI24490
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