Version 5.4
Mus musculus Protein: Plekha7
Summary
InnateDB Protein IDBP-207371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plekha7
Protein Name pleckstrin homology domain containing, family A member 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081714
InnateDB Gene IDBG-207369 (Plekha7)
Protein Structure
UniProt Annotation
Function Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, adherens junction {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0070097 delta-catenin binding
Biological Process
GO:0045218 zonula adherens maintenance
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005915 zonula adherens
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2445094
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UIL6
PhosphoSite PhosphoSite-Q3UIL6
TrEMBL
UniProt Splice Variant
Entrez Gene 233765
UniGene
RefSeq NP_766331
MGI ID
MGI Symbol Plekha7
OMIM
CCDS CCDS40099
HPRD
IMGT
EMBL AK040271 AK146866 AK160810 BC084587 EU380771 EU380772
GenPept AAH84587 ACB38003 ACB38004 BAC30557 BAE27490 BAE36027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca