InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arl6ip1

Summary

InnateDB Protein

IDBP-207512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl6ip1

Protein Name

ADP-ribosylation factor-like 6 interacting protein 1

Synonyms

Aip-1; AIP-6; AL022945; Arl6ip; ARMER; AU042858; C85138; mKIAA0069;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032888

InnateDB Gene

IDBG-207510 (Arl6ip1)

Protein Structure

UniProt Annotation

Function

May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Predominantly localized to intracytoplasmic membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all hematopoietic cell lineages, with highest levels in early myeloid progenitor cells. {ECO:0000269PubMed:10995579}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006613

cotranslational protein targeting to membrane

Cellular Component

GO:0005737	cytoplasm
GO:0005784	Sec61 translocon complex
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1858943

InterPro

IPR003388 Reticulon

PFAM

PF02453

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JKW0

PhosphoSite

PhosphoSite-Q9JKW0

TrEMBL

Q80ZW9

UniProt Splice Variant

Entrez Gene

54208

UniGene

Mm.474048

RefSeq

NP_062292

MGI ID

MGI Symbol

Arl6ip1

OMIM

CCDS

CCDS21769

HPRD

IMGT

EMBL

AF133669 AF172088 AF223953 AK150042 AK150507 AK151046 AK151272 AK151507 AK152565 AK152885 AK154355 AK154644 AK163655 AK167872 AK167888 AK168245 AK169191 BC010196 BC046792 CH466531 EF437380

GenPept

AAD33046 AAF27313 AAF34706 AAH10196 AAH46792 ABS83538 BAE29263 BAE29620 BAE30063 BAE30259 BAE30458 BAE31318 BAE31569 BAE32534 BAE32735 BAE37441 BAE39887 BAE39901 BAE40195 BAE40967 EDL17117 EDL17122