InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cnih3

Summary

InnateDB Protein

IDBP-207540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnih3

Protein Name

cornichon homolog 3 (Drosophila)

Synonyms

2900075G08Rik; CNIH-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027795

InnateDB Gene

IDBG-207538 (Cnih3)

Protein Structure

UniProt Annotation

Function

Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0035556	intracellular signal transduction
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0016020	membrane
GO:0030054	cell junction
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043198	dendritic shaft
GO:0045211	postsynaptic membrane