Version 5.4
Mus musculus Protein: Gabrd
Summary
InnateDB Protein IDBP-207546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gabrd
Protein Name gamma-aminobutyric acid (GABA) A receptor, subunit delta
Synonyms AI853201;
Species Mus musculus
Ensembl Protein ENSMUSP00000030925
InnateDB Gene IDBG-207544 (Gabrd)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:95622
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008098 Gamma-aminobutyric-acid A receptor delta subunit
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01722
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22933
PhosphoSite PhosphoSite-P22933
TrEMBL Q14AH9
UniProt Splice Variant
Entrez Gene 14403
UniGene Mm.388925
RefSeq NP_032098
MGI ID
MGI Symbol Gabrd
OMIM
CCDS CCDS19028
HPRD
IMGT
EMBL AH001900 BC116832 BC116836 CH466594 S42882
GenPept AAA37652 AAB22967 AAI16833 AAI16837 EDL15002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca