InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRTN

Summary

InnateDB Protein

IDBP-20766.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRTN

Protein Name

neurturin

Synonyms

NTN;

Species

Homo sapiens

Ensembl Protein

ENSP00000302648

InnateDB Gene

IDBG-20764 (NRTN)

Protein Structure

UniProt Annotation

Function

Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

Subcellular Localization

Secreted.

Disease Associations

Note=Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0000165	MAPK cascade
GO:0001755	neural crest cell migration
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0021675	nerve development
GO:0031175	neuron projection development