Version 5.4
Mus musculus Protein: Gde1
Summary
InnateDB Protein IDBP-207727.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gde1
Protein Name glycerophosphodiester phosphodiesterase 1
Synonyms 1200003M13Rik; Mir16; RGS16;
Species Mus musculus
Ensembl Protein ENSMUSP00000046371
InnateDB Gene IDBG-207725 (Gde1)
Protein Structure
UniProt Annotation
Function Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:10760272}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
GO:0046872 metal ion binding
GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006629 lipid metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1891827
InterPro IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JL56
PhosphoSite PhosphoSite-
TrEMBL D3Z3E2
UniProt Splice Variant
Entrez Gene 56209
UniGene Mm.273142
RefSeq NP_062526
MGI ID
MGI Symbol Gde1
OMIM
CCDS CCDS21774
HPRD
IMGT
EMBL AC152412 AF212860 AK005361 AK150807 BC003902
GenPept AAF65232 AAH03902 BAB23975 BAE29870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca