InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp23

Summary

InnateDB Protein

IDBP-207736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp23

Protein Name

matrix metallopeptidase 23

Synonyms

CA-MMP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030937

InnateDB Gene

IDBG-207734 (Mmp23)

Protein Structure

UniProt Annotation

Function

Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane {ECO:0000269PubMed:10471791}; Single-pass type II membrane protein {ECO:0000269PubMed:10471791}. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at relatively high level in heart, lung and spleen. Not detected in brain, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:10471791}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0000003	reproduction
GO:0006508	proteolysis

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1347361

InterPro

IPR001818 Peptidase M10, metallopeptidase
IPR003582 ShKT domain
IPR006026 Peptidase, metallopeptidase
IPR007110 Immunoglobulin-like domain
IPR021190 Peptidase M10A

PFAM

PF00413
PF01549

PRINTS

PR00138

PIRSF

SMART

SM00254
SM00235

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt