InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Daglb

Summary

InnateDB Protein

IDBP-207744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Daglb

Protein Name

diacylglycerol lipase, beta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043088

InnateDB Gene

IDBG-207742 (Daglb)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

In embryonic brains, it is present in axonal tracts, while in adults it localizes to dendritic fields, correlating with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment (at protein level). {ECO:0000269PubMed:14610053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0007405	neuroblast proliferation
GO:0016042	lipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0022008	neurogenesis
GO:0042136	neurotransmitter biosynthetic process
GO:0045087	innate immune response (InnateDB)