InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mib2

Summary

InnateDB Protein

IDBP-207750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mib2

Protein Name

mindbomb homolog 2 (Drosophila)

Synonyms

2210008I11Rik; skd; Zzank1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099465

InnateDB Gene

IDBG-207748 (Mib2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. {ECO:0000269PubMed:15824097}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15824097}. Endosome {ECO:0000269PubMed:15824097}. Note=Colocalizes with endosomal compartments.

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, liver and kidney. {ECO:0000269PubMed:15824097}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005769	early endosome

Protein Structure and Domains

PDB ID

MGI:2679684

InterPro

IPR000433 Zinc finger, ZZ-type
IPR001841 Zinc finger, RING-type
IPR002110 Ankyrin repeat
IPR010606 Mib-herc2
IPR020683 Ankyrin repeat-containing domain

PFAM