InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rac1

Summary

InnateDB Protein

IDBP-207767.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Rac1

Protein Name

RAS-related C3 botulinum substrate 1

Synonyms

AL023026; D5Ertd559e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098058

InnateDB Gene

IDBG-207763 (Rac1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 148 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	56 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	148 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0002093	auditory receptor cell morphogenesis
GO:0003382	epithelial cell morphogenesis
GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0006972	hyperosmotic response
GO:0007010	cytoskeleton organization
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0010592	positive regulation of lamellipodium assembly
GO:0015031	protein transport
GO:0016358	dendrite development
GO:0016477	cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021831	embryonic olfactory bulb interneuron precursor migration
GO:0030032	lamellipodium assembly
GO:0030041	actin filament polymerization
GO:0030334	regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0031529	ruffle organization
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045216	cell-cell junction organization
GO:0048532	anatomical structure arrangement
GO:0048813	dendrite morphogenesis
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0071542	dopaminergic neuron differentiation
GO:0072659	protein localization to plasma membrane
GO:0090103	cochlea morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0019897	extrinsic component of plasma membrane
GO:0030027	lamellipodium
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

MGI:97845

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt