InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epx

Summary

InnateDB Protein

IDBP-207789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epx

Protein Name

eosinophil peroxidase

Synonyms

EPO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050497

InnateDB Gene

IDBG-207787 (Epx)

Protein Structure

UniProt Annotation

Function

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. {ECO:0000250}.

Subcellular Localization

Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0002215	defense response to nematode
GO:0006979	response to oxidative stress
GO:0032693	negative regulation of interleukin-10 production
GO:0032714	negative regulation of interleukin-5 production
GO:0032753	positive regulation of interleukin-4 production
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process
GO:0072677	eosinophil migration