Mus musculus Protein: Atad3a | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-207803.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Atad3a | ||||||||||||||||||
Protein Name | ATPase family, AAA domain containing 3A | ||||||||||||||||||
Synonyms | 2400004H09Rik; Atad3; mKIAA1273; Tob3; | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000030903 | ||||||||||||||||||
InnateDB Gene | IDBG-207801 (Atad3a) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids (By similarity). {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in heart, spleen, kidney, liver and at smaller levels, in lung and muscle (at protein level). {ECO:0000269PubMed:20332122}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:1919214 | ||||||||||||||||||
InterPro |
IPR003593
AAA+ ATPase domain IPR003959 ATPase, AAA-type, core IPR021911 ATPase family AAA domain-containing protein 3, domain of unknown function DUF3523 IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00004
PF07724 PF13304 PF12037 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00382
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q925I1 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q925I1 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 108888 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NP_849534 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Atad3a | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS19037 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF343079 AK075921 AK148974 AK149702 AK150037 AK166099 AK172038 AK173141 AL670236 BC023301 BC058373 BC060036 CH466594 | ||||||||||||||||||
GenPept | AAH23301 AAH58373 AAH60036 AAK38648 BAC36055 BAD32419 BAE28707 BAE29037 BAE29259 BAE38570 BAE42791 CAM18382 EDL15028 | ||||||||||||||||||