InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dynll2

Summary

InnateDB Protein

IDBP-207853.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dynll2

Protein Name

dynein light chain LC8-type 2

Synonyms

1700064A15Rik; 6720463E02Rik; C87222; Dlc2; DLC8; DLC8b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020775

InnateDB Gene

IDBG-207851 (Dynll2)

Protein Structure

UniProt Annotation

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:14561217}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0007017	microtubule-based process
GO:0008039	synaptic target recognition
GO:0008152	metabolic process
GO:0046907	intracellular transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030286	dynein complex