InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bhlha15

Summary

InnateDB Protein

IDBP-208045.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bhlha15

Protein Name

basic helix-loop-helix family, member a15

Synonyms

1810009C13Rik; Bhlhb8; MIST-1; Mist1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055493

InnateDB Gene

IDBG-208043 (Bhlha15)

Protein Structure

UniProt Annotation

Function

Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3'. {ECO:0000269PubMed:15003629, ECO:0000269PubMed:15665001, ECO:0000269PubMed:9482738}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in pancreatic tissue only in acinar cells. There is a complete absence of expression in intra- or interlobular pancreatic ducts and in all islet cells. {ECO:0000269PubMed:11696558}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006851	mitochondrial calcium ion transport
GO:0007030	Golgi organization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0019722	calcium-mediated signaling
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048312	intracellular distribution of mitochondria
GO:0048469	cell maturation