InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Baiap2l1

Summary

InnateDB Protein

IDBP-208136.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Baiap2l1

Protein Name

BAI1-associated protein 2-like 1

Synonyms

1300006M19Rik; AI585895; IRTKS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053129

InnateDB Gene

IDBG-208134 (Baiap2l1)

Protein Structure

UniProt Annotation

Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level). {ECO:0000269PubMed:17430976}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007165	signal transduction
GO:0009617	response to bacterium
GO:0030838	positive regulation of actin filament polymerization
GO:0045087	innate immune response (InnateDB)
GO:0046847	filopodium assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0070062	extracellular vesicular exosome