Version 5.4
Mus musculus Protein: Tnfrsf18
Summary
InnateDB Protein IDBP-208290.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf18
Protein Name tumor necrosis factor receptor superfamily, member 18
Synonyms AITR; Gitr;
Species Mus musculus
Ensembl Protein ENSMUSP00000099462
InnateDB Gene IDBG-208288 (Tnfrsf18)
Protein Structure
UniProt Annotation
Function Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity). {ECO:0000250}.
Subcellular Localization Isoform A: Cell membrane; Single-pass type I membrane protein.Isoform B: Cell membrane; Single-pass type I membrane protein.Isoform C: Cell membrane; Single-pass type I membrane protein.Isoform D: Secreted.
Disease Associations
Tissue Specificity Preferentially expressed in activated T lymphocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:894675
InterPro IPR001368 TNFR/NGFR cysteine-rich region
IPR022318 Tumour necrosis factor receptor 18
PFAM PF00020
PRINTS PR01968
PIRSF
SMART SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35714
PhosphoSite PhosphoSite-
TrEMBL Q540M6
UniProt Splice Variant
Entrez Gene 21936
UniGene Mm.3180
RefSeq NP_033426
MGI ID
MGI Symbol Tnfrsf18
OMIM
CCDS CCDS19056
HPRD
IMGT
EMBL AF109216 AF229432 AF229433 AF229434 AK020762 AY157832 AY157833 CH466594 U82534
GenPept AAB81243 AAF14231 AAF61566 AAF61567 AAF61568 AAO21307 AAO21308 BAC25639 EDL15072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca