InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crym

Summary

InnateDB Protein

IDBP-208346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crym

Protein Name

crystallin, mu

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033198

InnateDB Gene

IDBG-208344 (Crym)

Protein Structure

UniProt Annotation

Function

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0042562	hormone binding
GO:0042803	protein homodimerization activity
GO:0047127	thiomorpholine-carboxylate dehydrogenase activity
GO:0050661	NADP binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0007605	sensory perception of sound
GO:0042403	thyroid hormone metabolic process
GO:0055114	oxidation-reduction process
GO:0070327	thyroid hormone transport