Version 5.4
Mus musculus Protein: Dstn
Summary
InnateDB Protein IDBP-208374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dstn
Protein Name destrin
Synonyms 2610043P17Rik; ADF; AU042046; corn1; Dsn; sid23p;
Species Mus musculus
Ensembl Protein ENSMUSP00000099461
InnateDB Gene IDBG-208372 (Dstn)
Protein Structure
UniProt Annotation
Function Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006928 cellular component movement
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1929270
InterPro IPR002108 Actin-depolymerising factor homology domain
IPR017904 ADF/Cofilin/Destrin
PFAM PF00241
PRINTS PR00006
PIRSF
SMART SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R0P5
PhosphoSite PhosphoSite-Q9R0P5
TrEMBL Q4FK36
UniProt Splice Variant
Entrez Gene 56431
UniGene Mm.28919
RefSeq NP_062745
MGI ID
MGI Symbol Dstn
OMIM
CCDS CCDS16812
HPRD
IMGT
EMBL AB025406 AK078898 BC131926 CH466519 CT010216
GenPept AAI31927 BAA84691 BAC37447 CAJ18424 EDL28434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca