InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tom1l1

Summary

InnateDB Protein

IDBP-208390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tom1l1

Protein Name

target of myb1-like 1 (chicken)

Synonyms

2310045L10Rik; C80573; Srcasm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020849

InnateDB Gene

IDBG-208388 (Tom1l1)

Protein Structure

UniProt Annotation

Function

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. {ECO:0000269PubMed:11711534}.

Subcellular Localization

Golgi apparatus, Golgi stack. Endosome membrane {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=A small proportion is membrane-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in brain and kidney, expressed at intermediate levels skin and heart, and weakly expressed in thymus. Not expressed in liver and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0030276	clathrin binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0006886	intracellular protein transport
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0031954	positive regulation of protein autophosphorylation
GO:0032147	activation of protein kinase activity
GO:0045839	negative regulation of mitosis
GO:0045860	positive regulation of protein kinase activity