InnateDB Protein
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IDBP-208457.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ovol2
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Protein Name
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ovo-like 2 (Drosophila)
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Synonyms
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1700108N11Rik; 1810007D21Rik; M-OVO; M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099460
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InnateDB Gene
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IDBG-208455 (Ovol2)
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Protein Structure
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Function |
Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. {ECO:0000269PubMed:15225875, ECO:0000269PubMed:16423343, ECO:0000269PubMed:23319585, ECO:0000269PubMed:24735878, ECO:0000269PubMed:24735879}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:9468311}.
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Disease Associations |
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Tissue Specificity |
Expressed highly in testis, specifically in spermatocytes. Expressed also in skin and at lower levels in the ovary. {ECO:0000269PubMed:12213202, ECO:0000269PubMed:15225875, ECO:0000269PubMed:9468311}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0044212
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transcription regulatory region DNA binding
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1338039
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CIV7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
107586
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UniGene |
Mm.399544
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RefSeq |
NP_694455
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MGI ID |
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MGI Symbol |
Ovol2
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OMIM |
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CCDS |
CCDS16818
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HPRD |
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IMGT |
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EMBL |
AB101294
AB101295
AB101296
AB101299
AK007360
AL808123
AY090537
AY090538
BC031771
BC057210
BC094445
CH466519
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GenPept |
AAH31771
AAH57210
AAH94445
AAM11991
AAM11992
BAB24985
BAD29939
BAD29940
BAD29941
BAD29942
BAD29943
BAD29944
CAM26789
EDL28455
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