InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ovol2

Summary

InnateDB Protein

IDBP-208457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ovol2

Protein Name

ovo-like 2 (Drosophila)

Synonyms

1700108N11Rik; 1810007D21Rik; M-OVO; M-OVO-A; M-OVO-B; MOVO; movo2; Ovo2; Zfp339;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099460

InnateDB Gene

IDBG-208455 (Ovol2)

Protein Structure

UniProt Annotation

Function

Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. {ECO:0000269PubMed:15225875, ECO:0000269PubMed:16423343, ECO:0000269PubMed:23319585, ECO:0000269PubMed:24735878, ECO:0000269PubMed:24735879}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9468311}.

Disease Associations

Tissue Specificity

Expressed highly in testis, specifically in spermatocytes. Expressed also in skin and at lower levels in the ovary. {ECO:0000269PubMed:12213202, ECO:0000269PubMed:15225875, ECO:0000269PubMed:9468311}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001755	neural crest cell migration
GO:0001842	neural fold formation
GO:0001947	heart looping
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010837	regulation of keratinocyte proliferation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0045617	negative regulation of keratinocyte differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048557	embryonic digestive tract morphogenesis
GO:0051726	regulation of cell cycle
GO:0060214	endocardium formation
GO:0060347	heart trabecula formation
GO:0060716	labyrinthine layer blood vessel development