Version 5.4
Mus musculus Protein: Arpc1a
Summary
InnateDB Protein IDBP-208495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc1a
Protein Name actin related protein 2/3 complex, subunit 1A
Synonyms 0610010H08Rik; 1110030K07Rik; 41kDa; AA407347; Sid32; Sid329;
Species Mus musculus
Ensembl Protein ENSMUSP00000031625
InnateDB Gene IDBG-208493 (Arpc1a)
Protein Structure
UniProt Annotation
Function Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0030833 regulation of actin filament polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1928896
InterPro IPR001680 WD40 repeat
IPR017383 ARP2/3 complex, 41kDa subunit (p41-arc)
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF PIRSF038093
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R0Q6
PhosphoSite PhosphoSite-Q9R0Q6
TrEMBL D3YVI5
UniProt Splice Variant
Entrez Gene 56443
UniGene Mm.371610
RefSeq NP_062741
MGI ID
MGI Symbol Arpc1a
OMIM
CCDS CCDS19855
HPRD
IMGT
EMBL AB024984 AC110556 AK076107 AK145663 BC001988
GenPept AAH01988 BAA84685 BAC36187 BAE26575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca