InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uqcrc2

Summary

InnateDB Protein

IDBP-208498.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uqcrc2

Protein Name

ubiquinol cytochrome c reductase core protein 2

Synonyms

1500004O06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033176

InnateDB Gene

IDBG-208496 (Uqcrc2)

Protein Structure

UniProt Annotation

Function

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005750	mitochondrial respiratory chain complex III
GO:0070062	extracellular vesicular exosome