InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smyd2

Summary

InnateDB Protein

IDBP-208504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smyd2

Protein Name

SET and MYND domain containing 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027897

InnateDB Gene

IDBG-208502 (Smyd2)

Protein Structure

UniProt Annotation

Function

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269PubMed:16805913}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in heart, skeletal muscle and brain tissue. During cardiac development, it is differentially expressed with highest expression in the neonatal heart while very low expression is detected at E12.5 and adult. Specifically expressed in cardiomyocytes (at protein level). {ECO:0000269PubMed:20305823}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0046872	metal ion binding
GO:0046975	histone methyltransferase activity (H3-K36 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0010452	histone H3-K36 methylation
GO:0016571	histone methylation
GO:0018026	peptidyl-lysine monomethylation
GO:0018027	peptidyl-lysine dimethylation
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator