Version 5.4
Mus musculus Protein: Dtd1
Summary
InnateDB Protein IDBP-208620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dtd1
Protein Name D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae)
Synonyms 0610006H08Rik; DUE-B; Hars2;
Species Mus musculus
Ensembl Protein ENSMUSP00000028917
InnateDB Gene IDBG-208618 (Dtd1)
Protein Structure
UniProt Annotation
Function ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000305}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0008150 biological_process
GO:0019478 D-amino acid catabolic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913294
InterPro IPR003732 D-tyrosyl-tRNA(Tyr) deacylase
IPR023509 D-Tyr tRNAtyr deacylase-like domain
PFAM PF02580
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DD18
PhosphoSite PhosphoSite-Q9DD18
TrEMBL
UniProt Splice Variant
Entrez Gene 66044
UniGene
RefSeq NP_079590
MGI ID
MGI Symbol Dtd1
OMIM
CCDS CCDS16824
HPRD
IMGT
EMBL AK003594 AK010822 AK011917 AK017565 AK158898 AL808119 AL844516 BC026537
GenPept AAH26537 BAB22882 BAB27205 BAB27914 BAB30808 BAE34719 CAM22364 CAM26713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca