InnateDB Protein
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IDBP-20871.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHP2
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Protein Name
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Calcineurin B homologous protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000300113
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InnateDB Gene
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IDBG-20869 (CHP2)
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Protein Structure
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Function |
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269PubMed:12226101, ECO:0000269PubMed:18815128}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21392185}. Cytoplasm {ECO:0000269PubMed:21392185}. Cell membrane {ECO:0000269PubMed:21392185}. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in malignantly transformed cells but not detected in normal tissues. {ECO:0000269PubMed:12097419, ECO:0000269PubMed:12226101}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008284
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positive regulation of cell proliferation
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GO:0010922
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positive regulation of phosphatase activity
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GO:0015031
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protein transport
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GO:0042307
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positive regulation of protein import into nucleus
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0070886
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positive regulation of calcineurin-NFAT signaling cascade
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GO:0071277
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cellular response to calcium ion
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Cellular Component |
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PDB ID |
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
O43745
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PhosphoSite |
PhosphoSite-O43745
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
63928
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UniGene |
Hs.178589
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RefSeq |
NP_071380
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HUGO |
HGNC:24927
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OMIM |
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CCDS |
CCDS10617
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HPRD |
14259
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IMGT |
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EMBL |
AC130454
AF146019
AK290253
AK313062
CH471145
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GenPept |
AAG14945
BAF82942
BAG35891
EAW55801
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