Version 5.4
Mus musculus Protein: Nenf
Summary
InnateDB Protein IDBP-208728.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nenf
Protein Name neuron derived neurotrophic factor
Synonyms 1110060M21Rik; SCIRP10; Spuf;
Species Mus musculus
Ensembl Protein ENSMUSP00000046311
InnateDB Gene IDBG-208726 (Nenf)
Protein Structure
UniProt Annotation
Function Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme. {ECO:0000269PubMed:15605373, ECO:0000269PubMed:16547973, ECO:0000269PubMed:18056703}.
Subcellular Localization Secreted, extracellular space {ECO:0000269PubMed:15605373}.
Disease Associations
Tissue Specificity In the embryo, expressed most abundantly in brain and spinal cord. Widely expressed in adult tissues including brain, heart, lung and kidney. In brain, expressed in neurons but not in glial cells. {ECO:0000269PubMed:15605373}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0043410 positive regulation of MAPK cascade
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1913458
InterPro IPR001199 Cytochrome b5-like heme/steroid binding domain
PFAM PF00173
PRINTS PR00363
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQ45
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66208
UniGene
RefSeq NP_079700
MGI ID
MGI Symbol Nenf
OMIM
CCDS CCDS15618
HPRD
IMGT
EMBL AB126218 AK002413 AK004329 AK009304 AK020403 AK155319 BC048464
GenPept AAH48464 BAB22081 BAB23264 BAB26205 BAB32092 BAD72062 BAE33187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca