InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp2r5a

Summary

InnateDB Protein

IDBP-208752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp2r5a

Protein Name

protein phosphatase 2, regulatory subunit B (B56), alpha isoform

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070726

InnateDB Gene

IDBG-208750 (Ppp2r5a)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in thymus and ovary. {ECO:0000269PubMed:15095873}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0019900	kinase binding

Biological Process

GO:0007165	signal transduction
GO:0035307	positive regulation of protein dephosphorylation
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090219	negative regulation of lipid kinase activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030018	Z disc
GO:0031430	M band