InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp3a11

Summary

InnateDB Protein

IDBP-208762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp3a11

Protein Name

cytochrome P450, family 3, subfamily a, polypeptide 11

Synonyms

AI256190; Cyp3a; IIIAm1; Pcn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037665

InnateDB Gene

IDBG-208760 (Cyp3a11)

Protein Structure

UniProt Annotation

Function

Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:88609

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV
IPR008072 Cytochrome P450, E-class, CYP3A

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00464
PR00465
PR01689

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64459