InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ears2

Summary

InnateDB Protein

IDBP-208830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ears2

Protein Name

glutamyl-tRNA synthetase 2 (mitochondrial)(putative)

Synonyms

3230401I01Rik; AL024049; mKIAA1970;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033159

InnateDB Gene

IDBG-208828 (Ears2)

Protein Structure

UniProt Annotation

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0004818	glutamate-tRNA ligase activity
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0050561	glutamate-tRNA(Gln) ligase activity

Biological Process

GO:0006424	glutamyl-tRNA aminoacylation
GO:0043039	tRNA aminoacylation
GO:0070127	tRNA aminoacylation for mitochondrial protein translation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1914667

InterPro

IPR000924 Glutamyl/glutaminyl-tRNA synthetase
IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial
IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain

PFAM

PF00749

PRINTS

PR00987

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CXJ1