Version 5.4
Mus musculus Protein: Usp12
Summary
InnateDB Protein IDBP-208869.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp12
Protein Name ubiquitin specific peptidase 12
Synonyms Ubh1;
Species Mus musculus
Ensembl Protein ENSMUSP00000082754
InnateDB Gene IDBG-208865 (Usp12)
Protein Structure
UniProt Annotation
Function Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
Cellular Component
Protein Structure and Domains
PDB ID MGI:1270128
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM PF00443
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D9M2
PhosphoSite PhosphoSite-Q9D9M2
TrEMBL
UniProt Splice Variant
Entrez Gene 22217
UniGene Mm.398464
RefSeq NP_035799
MGI ID
MGI Symbol Usp12
OMIM
CCDS CCDS39395
HPRD
IMGT
EMBL AF441835 AK006739 AK035629 AK167153 BC049274 BC055398 BC068136
GenPept AAH49274 AAH55398 AAH68136 AAL86740 BAB24720 BAC29129 BAE39295

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca