InnateDB Protein
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IDBP-208872.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Palb2
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Protein Name
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partner and localizer of BRCA2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000063514
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InnateDB Gene
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IDBG-208870 (Palb2)
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Protein Structure
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Function |
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus. Note=Colocalizes with BRCA2 in nuclear foci. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3040695
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InterPro |
IPR017986
WD40-repeat-containing domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3U0P1
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PhosphoSite |
PhosphoSite-Q3U0P1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
233826
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UniGene |
Mm.38348
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RefSeq |
NP_001276774
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MGI ID |
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MGI Symbol |
Palb2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK028653
AK156701
BC055302
BC066140
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GenPept |
AAH55302
AAH66140
BAC26048
BAE33811
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