InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc30a1

Summary

InnateDB Protein

IDBP-208892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc30a1

Protein Name

solute carrier family 30 (zinc transporter), member 1

Synonyms

AI839647; C130040I11Rik; Znt1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042410

InnateDB Gene

IDBG-208890 (Slc30a1)

Protein Structure

UniProt Annotation

Function

May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0005515	protein binding
GO:0008324	cation transmembrane transporter activity
GO:0019855	calcium channel inhibitor activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006812	cation transport
GO:0006829	zinc ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006882	cellular zinc ion homeostasis
GO:0046929	negative regulation of neurotransmitter secretion
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070574	cadmium ion transmembrane transport
GO:0071577	zinc ion transmembrane transport
GO:0071584	negative regulation of zinc ion import
GO:0071585	detoxification of cadmium ion
GO:0090281	negative regulation of calcium ion import

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0031965	nuclear membrane