InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkx2-2

Summary

InnateDB Protein

IDBP-208908.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkx2-2

Protein Name

NK2 transcription factor related, locus 2 (Drosophila)

Synonyms

Nkx-2.2; Nkx2.2; tinman;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069666

InnateDB Gene

IDBG-208906 (Nkx2-2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. {ECO:0000269PubMed:19759004}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:14573534}.

Disease Associations

Tissue Specificity

Expressed in restricted areas of the developing CNS: the hindbrain and forebrain, and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	6 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001159	core promoter proximal region DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0003323	type B pancreatic cell development
GO:0003326	pancreatic A cell fate commitment
GO:0003327	type B pancreatic cell fate commitment
GO:0003329	pancreatic PP cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007224	smoothened signaling pathway
GO:0007399	nervous system development
GO:0009749	response to glucose
GO:0014003	oligodendrocyte development
GO:0014070	response to organic cyclic compound
GO:0021522	spinal cord motor neuron differentiation
GO:0021529	spinal cord oligodendrocyte cell differentiation
GO:0021530	spinal cord oligodendrocyte cell fate specification
GO:0021554	optic nerve development
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0032570	response to progesterone
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048565	digestive tract development
GO:0048665	neuron fate specification
GO:0048708	astrocyte differentiation
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060580	ventral spinal cord interneuron fate determination